La Liga Picks — Predictions for Matchday 22 (Jan 31-Feb 3)
Important battles across the Spanish top-flight will be staged this weekend. Real Madrid will be aiming to extend their advantage...

Credit: AI Generated
Last updated Feb 8, 5:19pm EST
Important battles across the Spanish top-flight will be staged this weekend. Real Madrid will be aiming to extend their advantage at the summit when they travel to Espanyol, while Barcelona and Atletico Madrid are also both in action. You can find the La Liga picks for every clash on matchday 22 here.
La Liga Picks
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Leganes vs. Rayo Vallecano
Leganes have avoided defeat in their last three matches against Vallecano, but they have recorded just one win in their last 13 home derbies in La Liga. Vallecano also have a negative record in derbies after going three without a win.
The narrow preference is for the home win, as Leganes come into this round after going three without defeat.
Pick
Leganes (+208)
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Getafe vs. Sevilla
Getafe have recorded wins in two of their last four against Sevilla. However, the visitors have recorded five wins on their last seven trips to Getafe.
Sevilla recorded an away win in their last match, but Getafe’s recent form is hard to overlook after going four without a loss.
Pick
Getafe (+154)
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Villarreal vs. Valladolid
Villarreal come into this round of matches after winning four of their last five against Valladolid. Meanwhile, the hosts were 4-0 winners in their last home match, and could win two on the bounce at El Madrigal for the first time since May 2024.
Valladolid’s away form is hard to dismiss, as they have suffered defeats in each of their last five on the road.
Pick
Villarreal (-433)
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Atletico Madrid vs. Mallorca
Atletico Madrid have recorded wins in each of their last four against Mallorca, and they have kept three clean sheets over that period.
It would be a concern that Atletico have gone two without a win, but it shouldn’t be ignored that Mallorca have suffered defeats in each of their last four across all competitions.
Pick
Atletico Madrid (-223)
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Espanyol vs. Real Madrid
The hosts have a positive recent record in this fixture, winning two of their last five home matches against Real Madrid.
However, Los Blancos look to be clicking into gear at this stage, scoring in 33 of their last 34 matches against Espanyol, while they have collected 49 points from their opening 21 matches this season.
Pick
Real Madrid (-302)
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Barcelona vs. Alaves
Barcelona have avoided defeat in their last 14 La Liga matches against Alaves, winning 12 times over that period. However, Alaves have avoided defeat in their last three away matches this season.
Barcelona haven’t recorded back-to-back wins since November, but they will be among the prominent La Liga picks this weekend.
Pick
Barcelona (-490)
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Valencia vs. Celta Vigo
Valencia have failed to win in their last three against Celta Vigo, but in home matches, they have gone eight without defeat. The overall form of the hosts this season would be a major concern.
Last weekend, they conceded seven goals in a La Liga match for the first time since 1955. More misery could be inflicted this weekend.
Pick
Celta Vigo (+224)
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Osasuna vs. Real Sociedad
Real Sociedad have picked up points on their last eight trips to Osasuna in La Liga, winning eight times over that period.
However, they come into this round after losing three of their last four. But, the away win still looks to be among the standout La Liga picks, as Osasuna have failed to win in their last nine league matches.
Pick
Real Sociedad (+168)
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Real Betis vs. Athletic Bilbao
Betis boasts an excellent record in this fixture after avoiding defeat in five of their last six against Bilbao.
Meanwhile, the visitors have failed to win on their last six trips to Betis. A home win looks to be the standout chance based on the trends, but a draw could be preferred, as Bilbao have gone six without defeat on the road.
Pick
The Draw (+226)
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Girona vs. Las Palmas
Las Palmas ended a two-game losing sequence last weekend with a draw. However, Girona will have the pressure on their shoulders this weekend after losing each of their last three across all competitions.
A nervy match is expected, but the narrow preference is for the hosts to get back to winning ways.
Pick
Girona (-155)
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