Shane Baz starts for Baltimore after allowing 7 hits over 5.1 innings in his debut with the Orioles. The 26-year-old went 10-12 with a 4.87 ERA and 1.33 WHIP last year in 166.1 innings for Tampa Bay before getting traded to Baltimore in December.

Cade Horton takes the ball for Chicago after allowing 4 hits and a home run over 6.1 innings with a 2.84 ERA in his first start. The 24-year-old right-hander is coming off a phenomenal rookie season where he went 11-4 with a 2.67 ERA and 1.20 WHIP across 118 innings in 23 appearances.

Chad Patrick takes the ball for Milwaukee after allowing 5 hits and a home run over 4.1 innings with a 2.08 ERA in his first start. The 27-year-old right-hander is coming off an impressive rookie season where he went 3-8 with a 3.53 ERA and 1.28 WHIP across 119.2 innings in 27 appearances.

Emmet Sheehan gets the start for Los Angeles after a rough 2026 debut, allowing 5 hits and a home run over 3.1 innings with a 10.80 ERA. The 26-year-old right-hander is coming off a breakthrough 2025 campaign where he went 6-3 with a 2.82 ERA and 0.97 WHIP across 73.1 innings in 15 appearances including 12 starts.

Brady Singer gets the ball for Cincinnati after a short outing in his Reds debut, allowing 5 hits and a home run over just 4 innings with a 6.75 ERA. The 29-year-old right-hander is coming off a strong 2025 campaign where he went 14-12 with a 4.03 ERA and 1.24 WHIP across 169.2 innings in 32 starts. He relies heavily on his sinker-slider combination and finished strong last season with a 2.81 ERA over his final 12 starts.

Kyle Bradish missed much of the 2024 and 2025 seasons after undergoing Tommy John surgery. In 2023, he was a linchpin in the Orioles' rotation with a 4.8 bWAR, finishing 4th in the AL Cy Young Award voting. He was effective in his 2025 return, making 6 starts, posting a 2.53 ERA, and a 1.2 bWAR.

The Yankees' pitching has been superlative in winning 5 of their first 6 games on the road in San Francisco and Seattle, particularly the starting pitching. While Max Fried and Cam Schlittler are getting the attention, Will Warren and Ryan Weathers were also very good.

David Peterson has long been a frustrating performer for the Mets. He was a 1st round draft pick in 2017. He's inconsistent with his control, is not a strikeout pitcher, but keeps the ball in the park.

As the Twins navigate their new normal after ownership questions, parting ways with President of Baseball Ops Derek Falvey, firing manager Rocco Baldelli, and essentially clearing the decks at the 2025 trade deadline, they are finding their path forward.

Yusei Kikuchi enters his second start of 2026, trying to build on the success of his first Angels season. The southpaw went 7-11 with a 3.99 ERA, 1.42 WHIP, and 1.8 bWAR across 178.1 innings in 2025, earning his second All-Star selection.

Joe Ryan finished 13-10 with a 3.42 ERA, 1.04 WHIP, and 4.5 bWAR across 171 innings in 2025. He ranked fourth in the AL in strikeout percentage at 28.2% while posting the fifth-best walk rate at 5.7%.

Cam Schlittler made an emphatic statement in his first start of 2026, shutting down the Giants with just one hit over 5.1 innings while striking out eight. The 25-year-old rookie sensation is coming off a breakout 2025 campaign where he posted a 4-3 record with a 2.96 ERA in 14 starts, striking out 84 in 73 innings with a 1.22 WHIP.