Serie A Picks — Predictions for Matchday 21 (Jan 17-20)
The intense action in Italy’s top division continues between January 17 and 20, as the 21st round of matches are...

Credit: AI Generated
Last updated Feb 8, 5:18pm EST
The intense action in Italy’s top division continues between January 17 and 20, as the 21st round of matches are staged. It could be a pivotal round in the Serie A championship race, with Napoli looking to go six points clear at the summit. You can find our Serie A picks for matchday 21 below.
Serie A Picks
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Roma vs. Genoa
Genoa and Roma are separated by just a single point in the current standings, with both avoiding defeat in their previous three. However, the visitors have a better win-rate over that sequence, claiming maximum points in two of their last three. That momentum could be key in the Italian capital on Friday.
Pick
Genoa (+585)
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Bologna vs. Monza
Bologna would have gained huge confidence from their recent outing in Serie A, claiming a point against Inter Milan. But, the hosts have now played out ties in their last two and gone three without a win. Despite that, it is hard to make a case for Monza, who have won just twice in 20 league outings this season.
Pick
Bologna (-160)
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Juventus vs. AC Milan
The blockbuster showdown in Serie A this weekend takes place in Turin. Juventus have avoided defeat in 20 league matches this season, but a staggering 13 fixtures have ended in draws. Milan have been better since the change in management, winning two of their last four. Therefore, the narrow edge is given to the visitors.
Pick
AC Milan (+272)
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Atalanta vs. Napoli
Two of the top three collide, as Atalanta host Napoli. A win for the hosts would see them close the gap at the summit to a point. However, a three-game drawing sequence would be a concern for Atalanta. Napoli have been excellent since the winter break, and they look good value to record a sixth straight win.
Pick
Napoli (+252)
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Fiorentina vs. Torino
Torino have proven to be a difficult side to beat in recent weeks, playing out draws in their last three. Meanwhile, the opposite could be said of Fiorentina, who have lost four of their last five. The losing sequence of the home side means that a draw could be a viable betting angle this weekend.
Pick
The Draw (+250)
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Parma vs. Venezia
A huge game at the bottom of the standings sees Parma host Venezia. The hosts have won just once in their last five, while Venezia have avoided defeat in three over the same period. Little separates these sides, but Parma’s better attacking record could see them getting over the line.
Pick
Parma (+121)
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Cagliari vs. Lecce
Lecce and Cagliari both come into this round after winning once in their last two. However, Lecce’s poor attacking record sees them rank as the lowest scorers in Serie A. Therefore, the narrow preference is given to the home side, as they look to move out of the relegation place.
Pick
Cagliari (-106)
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Verona vs. Lazio
Lazio will see this Sunday’s clash against Verona as an opportunity to get back on track. The Rome-based club have gone three without a win, while Verona have conceded a league-high of 44 goals this season. Therefore, Lazio are preferred at the odds available when making Serie A picks.
Pick
Lazio (-127)
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Inter Milan vs. Empoli
Inter Milan will rank among the popular Serie A picks once again this weekend, despite dropping points in a recent draw against Bologna. Empoli’s recent form offers very little hope of a shock result, as they have suffered defeats in four of their last five league matches.
Pick
Inter Milan (-460)
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