Serie A Picks — Predictions for Matchday 22 (Jan 24-27)

A heavyweight weekend of Serie A action is set for matchday 22, with the standout clash seeing Napoli host Juventus. Blockbuster clashes are also set for La Liga and the Bundesliga this weekend, but you can find our Serie A picks for matchday 22 here.

Serie A Picks

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Torino vs. Cagliari

Cagliari are chasing just a third ever league double over Torino on Friday. The hosts have failed to win in their last five home matches, while they have played out draws in each of their last four. A fifth straight draw could be an interesting angle.

Como vs. Atalanta

Como recorded a 3-2 win in the reverse fixture this season, but they haven’t completed a double over their opponents since 1949-50. Atalanta have won on just one of their last nine trips to Como, but that trend could be reversed on Saturday.

Napoli vs. Juventus

Napoli have won their last five home matches against Juventus, scoring 12 goals and conceding just four over that period. The team from Naples have won 16 of their opening 21 matches this term, and that winning sequence could be the key angle against an inconsistent Old Lady.

Empoli vs. Bologna

Empoli have suffered defeats in five of their last six matches in Serie A. They have also suffered losses in each of their last three at home. Bologna appear to be the standout angle when making Serie A picks after going three without defeat against Empoli.

AC Milan vs. Parma

Milan hold obvious claims this weekend after losing just one of their last 20 matches against Parma at San Siro. However, it would be a slight concern that they have drawn four of their last five at home. That being said, the preference remains for the hosts.

Udinese vs. Roma

Roma have recorded wins in 54 of the 101 Serie A meetings between the sides, which includes victories in seven of the last nine. Roma should come into this round in good confidence after a win over Genoa last weekend, and that could be the difference-maker on Sunday.

Lecce vs. Inter Milan

Inter Milan have recorded wins in their last five matches against Lecce, scoring at least twice in every victory over that period. Inter’s away record is also a key angle to consider, as they have won each of their last seven on the road ahead of this weekend’s clash.

Lazio vs. Fiorentina

Fiorentina will be chasing a first league double over Lazio since 2012-13 on Sunday. However, Lazio are unbeaten in their last eight home matches against Fiorentina. Their form has been excellent in recent weeks, while the team from Florence has been below their best in 2025.

Venezia vs. Verona

Verona have avoided defeat in their last seven Serie A matches against Venezia. However, Venezia have avoided defeat in five of their last seven matches. The chances of a home win are also improved based on the fact that Verona have failed to score in their last three matches.

Genoa vs. Monza

Genoa holds an excellent chance against Monza this week based on the trends. They have suffered just two defeats in their last eleven league matches, and they come into this showdown after avoiding defeat in 20 of their last 21 home matches against Monza.